Laser Line Scan Confocal Microscope | SIMTRUM Photonics Store

The third characteristic is large field of view (FOV) available. Our scientific CMOS camera can offer up to 5.5 Megapixel sensor, yielding the largest available field of view with 60x objectives (0.36 mm) and 40x objectives (0.54 mm). Maximizing view in fluorescence microscopy is of increasing relevance across a wide range of applications, including high content screening of large fields of cells, imaging of the developing embryo, neuron mapping and tissue imaging.

Features & Benefits

√ High-speed acquisition

√ Strong optical sectioning

√ Single molecule imaging

√ Multi-color fluorescence

√ High sensitivity

√ Large field of view

√ Low photobleaching and phototoxicity

√ Super-resolution

√ Intuitive software

LSFMM (Line-scan Focal Modulation Microscopy) is a novel microscopy method that has been developed to achieve a deeper penetration depth on the basis of confocal microscopy. Equivalently selective excitation is achieved by modulating the light intensity at the focal point only. Fluorescence emission or backscattered light are collected and demodulated. As a result, only focal signals are decoded and thus significantly reducing the background signals. Specially, we add a cylindrical lens to generate a line-focus at the sample and achieve line-scan imaging. Therefore, the imaging acquisition speed is improved significantly compared with conventional point-scan confocal microscopes.

 Chicken chondrocytes labelled with a lipid tracer

     3-day post-fertilized zebrafish heart labelled by EGFP

Automatical image acquisition 

GUI software

·   Immediate visual feedback on experimental progress to evaluate data and make appropriate 

    decisions in real-time

Upgrade to Fluorescence lifetime imaging microscopy (FLIM) 

FLIM is a type of microscopy that allows for the visualization and analysis of biological samples based on the fluorescence lifetime of the fluorophore being used. FLIM measures the time between the excitation and emission of photons in a sample, which can provide information about the properties of the fluorophore and the environment in which it is located.

FLIM can be used to study a wide range of biological processes, including protein-protein interactions, enzyme activity, and ion concentration changes. It is often used in combination with other imaging techniques, such as confocal microscopy, to provide more detailed information about the sample.

Upgrade to Single / Two /Multi Photon Microscope

In two-photon microscope, a laser emits light at a specific wavelength that is absorbed by the fluorescent molecules in the sample. When two photons of this light are absorbed simultaneously, they provide enough energy to excite the fluorescent molecule and cause it to emit light at a longer wavelength, which can be detected by the microscope. Because two photons are required to excite the molecule, the probability of fluorescence emission is low and only occurs at the focal point of the microscope, allowing for high-resolution imaging and greater depth than conventional microscopes.

Two-photon microscopy has a number of applications in neuroscience, biology, and biomedical imaging. For example, it has been used to study the activity of individual neurons in the brain, visualize the structure and function of blood vessels, and track the behavior of cells in living tissues.

Upgrade to Confocal Spectral Microscope (Near IR I/II Confocal)

● Upgrade to Confocal Spectral Microscope (NIR I/II confocal)

● Wavelength Range UV to NIR (200nm-2.5nm)

● Spectral resolution up to 0.2nm

● Large NA setup for high-sensitivity application

Details Click here

Upgrade to Terahertz Confocal Microscope System

● 100GHz, output power: 80mW

● Spatial resolution 150-200um

The terahertz confocal microscope uses a focused beam of terahertz radiation to scan the sample being analyzed. This beam is then reflected back and collected by a detector, which creates an image of the sample based on the intensity of the reflected radiation. By using a confocal design, this microscope can achieve high resolution and can selectively focus on different depths within a sample.

 it can be used to study the microstructure and properties of materials, such as polymers, ceramics, and semiconductors, and to detect defects or anomalies in their structures. In biology and medicine, it can be used to image and study biological tissues, including skin, teeth, and cartilage, which are transparent to terahertz radiation.

Upgrade to Super Resolution Confocal Re-scan Structure illumination Microscope

A "re-scan" confocal microscope is a type of confocal microscope that uses a rapidly moving mirror or scanner to scan the laser beam across the sample multiple times, producing even higher resolution and better contrast images than standard confocal microscopes.

Overall, re-scan confocal microscopes are very powerful tools for studying biological tissues, cells, and other samples, and are widely used in research labs, medical facilities, and other scientific settings

Compatible with SIMTRUM Cryostat to perform Low-temperature Raman measurements -190 to 600 degrees

● 8 probe arm able to upgrade to adjustable probe arm

● Reflection or transmission mode available

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