Sign In

  • Forgot your password?
  • Need a new account?

Register


Laser Scanning Confocal Microscope | SIMTRUM Photonics Store

Laser Point Scanning Confocal Microscope
SIMSCOP P Series Laser Scanning Confocal Microscope

Confocal Microscopy is an optical imaging technique for increasing the Optical Resolution and Contrast of a Micrograph by using a Spatial Pinhole to block out-of-focus light in image formation. Capturing multiple two-dimensional images at different depths in a specimen enables the reconstruction of three-dimensional imaging.

 

Our recently released “2+1” P series confocal microscope offers 2 channel imaging detector and  1 functional detection channel with several options. The ability to simultaneously collect signals from two channels can be advantageous for dynamic studies, such as tracking the movement of labeled particles or observing live cell processes. It allows you to capture multiple aspects of the sample's behavior in real-time. The presence of a functional channel allows you to capture spectral or lifetime information from the sample, making it suitable for a wide range of applications.

 

Furthermore, our XY Microscope Piezo Stages has been designed for use our SIMSCOP Series Microscopes to provide motorized XY positioning of microscopy  samples. Access for SIMTRUM's XY Microscope Stages can be click here.

 

Product Brochure Link: 

 

 

Key Advantage

  • 2 channels for simultaneous two-color imaging 
  • Higher acquisition speed
  • Flexible selection of laser lines and detector type
  • Adaptable to SIPM, PMT(MA), PMT(GaAsP), PMT(GaAs) 
  • Reserved channels support modular upgrades

         √ Raman spectrometer

         √ Fluorescence spectrometer

         √ TCSPC module

         √ NIR I/II detector

               
              

 

  • 2 detector channels enable simultaneous two-color imaging for faster imaging, You can use different fluorophores or fluorescent labels with distinct emission spectra and simultaneously capture their signals. This is especially useful for studying multiple targets or molecules within a sample without the need for sequential imaging.

 

 

  • Flexible selection of laser lines and detector type (GaAsP, PMT/MA, PMT/SIPM): The ability to choose detector type allows you to optimize SNR for your specific experimental requirements. The combination of multiple detectors and functional information allows for quantitative analysis of fluorescence intensities, emission spectra, and fluorescence lifetime measurements. This is crucial for many quantitative biology and materials science experiments.

 

Parameters SiPM GaAsP PMT Polyalkaline
PMT
Dual-alkali
(Ultra bialkali)
PMT
Photosentsitive Area 6mmx6mm Ø5 mm Ø8 mm Ø8 mm
Spectral Response Range (nm) 200-900 300-740 185-870 230-700
Peak Response Wavelength (nm) 420 520 400 400
Dark Current nA 900 3 1 1
Peak Wavelength Detection Efficiency 38%@420nm 45%@520nm 23.87%@400nm 40.3%@400nm
Rise Time 180ps 1ns 0.57ns 0.57ns

 

  • Advantages of SiPM detectors: Achieve higher QE and lower noise: low voltage operation, long life, wider dynamic range, insensitive to magnetic fields, suitable for high-speed high signal-to-noise ratio imaging.

Product specifications and Brochures

Product Brochure Link: 

 

SIMSCOP - P Series Point Scan Confocal Microscope
Laser Light Source Standard wavelength:405±5 nm; 488nm±5nm; 561nm±1nm; 640nm±5nm
Output mode:single-mode polarization-maintaining fiber (TEM00)
Single wavelength output power: >20mW; Power stability: <1%
Spectral linewidth: <3nm
TTL modulation, 1kHz
Accuracy of laser power adjustment: 0.1%; Multi-wavelength AOTF power adjustment
Optional wavelengths include 375nm/ 445nm/473nm/ 515nm/525nm /532nm/633nm /660nm/ 685nm/785nm/808nm
Detectors SiPM, 250-950nm QE25%@420nm, dark current: 618nA
Multi-alkali PMT, 300-650nm QE>30%@500nm, dark current: 10nA
GaAsP PMT,    300-740nm QE>45%@520nm, dark current: 3nA
Scan Module Scanning pixels 128x128 ~ 4096x4096
Pixel time 0.5 μs -100 μs
Maximum scanning speed: up to 8fps ( 512 x 512)
XY Resolution 230nm@100x Oil objective
Image Depth 100um
FOV 5X: 1.44mmx1.44mm  |  10x: 0.72mmx0.72mm  |  20x: 0.36mmx0.36mm,   
40x: 0.18mmx0.18mm  |  60x: 120umx120um  |  100x: 72umx72um
Filter Unit DAPI EM 445nm/50nm,     FITC EM 530nm/50nm
TRITC EM 605nm/60nm,   Cy5 EM 695nm/40nm
Pinhole 16 pinhole choices; Pinhole diameter range:Ø25 µm to Ø2 mm
Eyepiece WF10X/23 wide field eyepiece; High eye point; Centering telescope
Eyepiece Tube 45°inclined,50‒75mm adjustable interpupillary distance; Adjustable diopter
Objective Converter Converter with five-hole internal positioning ; Ball bearing for internal positioning
Stage Manual: 240mm x 260mm fixed stage; Range of movement:135mm x 85mm
Motorized: Minimum step size:50nm; Repeatability +/- 0.1 μm
Maximum speed≥100mm/s; Stage size:≥270x170mm
Stroke : X:110mm,Y:75mm; Maximum load capacity >1KG (Horizontal)
Z Driver Focusing resolution/minimum step size: 0.05μm; Repeatability: +/-0.2μm;
Maximum stroke:10mm
Focusing Mechanism Coaxial coarse/ fine adjustment with limit and locking devices,
Low level coaxial focusing handwheel ; Handwheel graduations of fine adjustment:1μm
Transmitted Illumination System Warm LED light, continuously adjustable brightness
Brightness adjuster with LED rotation
Condenser:72mm ultra-long working distance,NA=0.30; Equipped with a three-hole phase contrast annular plate
Epi-fluorescence
Illumination System
Multi-band LED light source MG-100
6-hole fluorescence module
UV(U)EX:375/30nm      DM:415EM:460/50nm
Blue(B)EX:475/30nm
    DM:505EM:530/40nm
Yellow(Y)EX:540/25nm
DM:565EM:605/55nm
Red(R)EX:620/50nm
    DM:655EM:692/45nm
Upgrade module
(optional)
Raman confocal spectrometer
Fluorescence spectrometer
TCSPC
NIR I/II detector
Software Feature Multi-color fluorescence localization processing; Z-stack data processing; Large image stitching; Image analysis; Imaging data management; 3D imaging reconstruction; Spectrum analysis

 

 

 

Professional Software UI Design

 

SIMSCOP CM Series Confocal Microscope Software Key Features

         

Laser Control Panel
         

Microscope Image Acquisition Parameter Settings
         
  Functional GUI Panel  
Easy-to-recognize display for setting lasers, detectors, etc. Camera parameter settings
Image processing & deconvolution

 


Upgrade to Confocal Raman Microscope

● 532,785,1064 Raman

● Upright Microscope setup

● High Resolution with Raman image mapping

Details Click here




Upgrade to Fluorescence lifetime imaging microscopy (FLIM) 

FLIM is a type of microscopy that allows for the visualization and analysis of biological samples based on the fluorescence lifetime of the fluorophore being used. FLIM measures the time between the excitation and emission of photons in a sample, which can provide information about the properties of the fluorophore and the environment in which it is located.


FLIM can be used to study a wide range of biological processes, including protein-protein interactions, enzyme activity, and ion concentration changes. It is often used in combination with other imaging techniques, such as confocal microscopy, to provide more detailed information about the sample.





Upgrade to Single / Two /Multi Photon Microscope

In two-photon microscope, a laser emits light at a specific wavelength that is absorbed by the fluorescent molecules in the sample. When two photons of this light are absorbed simultaneously, they provide enough energy to excite the fluorescent molecule and cause it to emit light at a longer wavelength, which can be detected by the microscope. Because two photons are required to excite the molecule, the probability of fluorescence emission is low and only occurs at the focal point of the microscope, allowing for high-resolution imaging and greater depth than conventional microscopes.


Two-photon microscopy has a number of applications in neuroscience, biology, and biomedical imaging. For example, it has been used to study the activity of individual neurons in the brain, visualize the structure and function of blood vessels, and track the behavior of cells in living tissues.






Upgrade to Confocal Spectral Microscope (Near IR I/II Confocal)

● Upgrade to Confocal Spectral Microscope (NIR I/II confocal)

● Wavelength Range UV to NIR (200nm-2.5nm)

● Spectral resolution up to 0.2nm

● Large NA setup for high-sensitivity application

Details Click here




Upgrade to High Speed Lines Scan Confocal Microscope

● Frame Rate 210fps 

● Resolution: 150 nm over the optical diffraction limit

● Imaging Depth of 500 to 1000 microns 

● Image Contract enhancement 20-30 dB


Click Here for More Info




Upgrade to Terahertz Confocal Microscope System

100GHz, output power: 80mW

● Spatial resolution 150-200um


The terahertz confocal microscope uses a focused beam of terahertz radiation to scan the sample being analyzed. This beam is then reflected back and collected by a detector, which creates an image of the sample based on the intensity of the reflected radiation. By using a confocal design, this microscope can achieve high resolution and can selectively focus on different depths within a sample.


 it can be used to study the microstructure and properties of materials, such as polymers, ceramics, and semiconductors, and to detect defects or anomalies in their structures. In biology and medicine, it can be used to image and study biological tissues, including skin, teeth, and cartilage, which are transparent to terahertz radiation.




Upgrade to Super Resolution Confocal Re-scan Structure illumination Microscope

A "re-scan" confocal microscope is a type of confocal microscope that uses a rapidly moving mirror or scanner to scan the laser beam across the sample multiple times, producing even higher resolution and better contrast images than standard confocal microscopes.


Overall, re-scan confocal microscopes are very powerful tools for studying biological tissues, cells, and other samples, and are widely used in research labs, medical facilities, and other scientific settings




Upgrade to Low Temperature Confocal Microscope

Compatible with SIMTRUM Cryostat to perform Low-temperature Raman measurements -190 to 600 degrees

● 8 probe arm able to upgrade to adjustable probe arm

● Reflection or transmission mode available



Point Scan Confocal Imaging Acquistion Altas

 

 

High-definition Visual Assets: Should you require high-definition authentic images and video footage, we invite you to get in touch with us.
BPAE cell 1, SIMSCOP Pseries, 60X objective lens   BPAE cell 2, SIMSCOP P series, 60X objective lens

BPAE cell 1, SIMSCOP P series, 60X objective lens

Laser 405nm, 488nm & 561nm (Original Image)

 

BPAE cell 2, SIMSCOP P series, 60X objective lens

Laser 405nm, 488nm & 561nm (Original Image)

     
Mouse nerve, SIMSCOP Pseries, 20X objective lens   Fibrous connective tissue section, SIMSCOP P Series, 10X objective lens_1000x1000

Mouse nerve, SIMSCOP Pseries, 20X objective lens

Detector SIPM (Original Image)

 

Fibrous connective tissue section, SIMSCOP P Series, 10X objective lens_1000x1000, Detector SIPM (Original Image)

     
Sago palm leaf, SIMSCOP Pseries, 10X objective lens_500x500   Sago palm leaf, SIMSCOP Pseries, 10X objective lens_800x800

Sago palm leaf, SIMSCOP Pseries, 10X objective lens_500x500

Detector SIPM (Original Image)

 

Sago palm leaf, SIMSCOP Pseries, 10X objective lens_800x800

Detector SIPM (Original Image)

 

 

 

 

 

 

 

 

 

 


Parameters

Basic

P Series Box

Basic

P Series

Advance

P Series

Basic

L Series

Advance

L Series

SpinDisk

Basic

SpinDisk

 Advance

SIM Basic SpinDisk SIM
Image Frame Rate 4fps@512x512 4fps@512x512 4fps@512x512 10fps@1024x1024 14fps@1024x1024 100fps@2048x2048 100fps@2048x2048 13fps@1024x1024 13fps@1024x1024
Resolution ~230 nm  ~230 nm  ~230 nm  ~230 nm  150-200nm ~230 nm  ~230 nm  ~100 nm  ~100 nm 
Image Depth <100µm <100µm <100µm <100µm <600µm <200µm <200µm <50µm <200µm
No. of Laser  1 1 4 1 4 4 4 4 4
Wavelength Choice 

405/445/488

/525/561/640(nm)

405/445/488/

525/561/640(nm)

405/488/561/

640(nm)

405/445/488/

525/561/640(nm)

405/488/561/

640(nm)

405/445/470/520/

528/555/640(nm)

405/445/470/520/

528/555/640(nm)

405/445/470/520/

528/555/640(nm)

405/445/470/520/

528/555/640(nm)

Detectors Detector Detector Detector CMOS Camera sCMOS Camera sCMOS Camera Dual sCMOS Camera(Single sCMOS optional) sCMOS Camera Dual sCMOS Camera(Single sCMOS optional)
Microscope  Non Inverted (Upright Customizeable) Inverted (Upright Customizeable) Inverted (Upright Customizeable) Inverted (Upright Customizeable)

Inverted or

Upright 

Inverted or

Upright 

Inverted or

Upright 

Inverted
Stages Non

Z Motorized

XY Manual

XYZ Motorized  Z Motorized
XY Manual
XYZ Motorized  XYZ Motorized  XYZ Motorized  XYZ Motorized  XYZ Motorized 
Electronics system     Motorized Filter
Motorized Pin hole
  Motorized Filter Motorized Filter Motorized Filter Motorized Filter Motorized Filter
image contrast Medium Medium High Medium High High High High High
Upgrade option Non Non Upgrade to 30fps high Speed  Non Non Non Upgrade to SPIN Disk SIM 100nm resolution Upgrade to SPIN Disk SIM 100nm resolution Non
Customized Option     Yes   Yes Yes Yes    
Applications Biomedicine: monochromatic fluorescence microscopic   observation of cells, 3D scanning; Biomedicine: monochromatic fluorescence microscopic   observation of cells, 3D scanning;
Biomedicine: three-dimensional fluorescence microscopy imaging observation of cells and tissues, multi-channel fluorescence detection
Reflective 3D microscopic imaging, surface shape detection,   rapid analysis and measurement of materials and microelectronic device   surface shape Fast 3D imaging of thick tissue, 3D histopathological image   detection, 3D histomorphological research of small animal tissues and organs   such as brain neurons, liver, kidney, etc. Dynamic fluorescence imaging of living cells/tissues,   microscopic observation of small animals such as zebrafish and nematodes Dynamic fluorescence imaging of living cells/tissues,   microscopic in vivo observation of small animals such as zebrafish and nematodes, and in vivo observation of multi-channel fluorescent organelles. Dynamic fluorescence super-resolution imaging of living cells   can be used for live cell dynamics, allowing tracking of biological changes   at cellular and subcellular levels Dynamic fluorescence super-resolution imaging of living cells,   3D imaging of tissues, organoids, spheroids and small organisms.

 

Wide Field Raman Microscope Fluorescence / Photoluminescence Microscope Time Correlated Single Photon Counting (TCSPC) For SPAD Testing 

 

XY Microscope Piezo Stages
Model ST-XY3-11075 ST-XY2-7550
Image    
Stroke(mm) 110 X 75 75 X 50
Driver Piezoelectric Motor Piezoelectric Motor
Maximum Load Capacity(KG) 1 1
Maximum Speed(mm/s) 100 100
Minimum Step Size(nm) 20 (50, 100nm for option) 50
Repeatability(nm) +/-200 +/-200
Position Sensor Grating Grating
Material Aluminum Alloy Aluminum Alloy
Weight(KG) 3.3 2.5

 

 

Multi-Line CW Single-Mode Laser
Item Number ST4LS-A ST4LS-B ST4LS-C
Image
Wavelength 405/488/532/640mm 405/488/561/640mm Based on our standard laser configurations (405/488/561/640 and 405/488/532/640), we offer customizable options for additional wavelengths, including but not limited to: UV: 375nm,VIS: 445nm, 473nm, 515nm, 525nm, 532nm, 633nm, 660nm, 685nm,NIR: 785nm, 808nm. For further customization beyond these options, please contact us for assistance
Fiber FC/APC
Length: 1 Meter
Core Diameter: 4-6 Micrometers
Customization is avaible
Output Power 20mW
Power Stability(rms, over 4 hours) <1%
Laser Noise 4%
Spectral Linewidth 3nm
Laser Power Adjustment Accuracy  Multiple Wavelength AOTF Power Adjustment Accuracy:0.1%; Without AOTF: 0.5mW
Working Mode Continuous Output, TTL Modulation, Analog Modulation for Option
Operating Temperature 10~35()
Power Supply 100~240VAC

 

 

 


We are here for you!




Drop us an email at info@simtrum.com to get the Best Price today.

Want more technical information? Click Here for the professional Customized System/ Solutions.




Don't have time to search the products one by one? No worries. you can download the full range of SIMTRUM Product Line Cards.

Click it now.


Want to stay closer to the Market Dynamics and Technological 

Developments? Just take 5 seconds to Sign In as a member of 

SIMTRUM, we will bring you the most up-to-date news. 

(Sign in button on the top right of the screen).




Search Reset
Compare Model Drawings & Specs Availability Reference Price
(USD)
SIMSCOP P Series
Laser Scanning Confocal Microscope, Standard Wavelength 405/488/561/640nm(638nm), dual-axis XY high-speed optical scanning galvanometer, field of view 15x15mm, scanning pixels 512x512 ~4096x4096, scan speed up to 4fps, stroke: X-110mm, Y-75mm, Z-9mm
In Stock Request for quote

SIMSCOP P Series - Parameter

SIMSCOP P Series - Download

Accessories

Compare Model Drawings & Specs Availability Reference Price
(USD)