Sign In

  • Forgot your password?
  • Need a new account?


Laser Scanning Confocal Microscope | SIMTRUM Photonics Store

Laser Scanning Confocal Microscope
SIMSCOP P Series Laser Scanning Confocal Microscope

Confocal Microscopy is an optical imaging technique for increasing the Optical Resolution and Contrast of a Micrograph by using a Spatial Pinhole to block out-of-focus light in image formation. Capturing multiple two-dimensional images at different depths in a specimen enables the reconstruction of three-dimensional imaging.


This technology is widely adopted in scientific and industrial, for life science, material, or semiconductor  inspection. However, the cost of the mature commercialized system is usually very high.


SIMTRUM see the needs of the customer to have a robust confocal microscope system with reasonable cost. Our SIMSCOP P Series offers a great balance between functionality, cost, and flexibility. 


Furthermore, our XY Microscope Piezo Stages has been designed for use our SIMSCOP Series Microscopes to provide motorized XY positioning of microscopy  samples. Access for SIMTRUM's XY Microscope Stages can be click here.

Key Advantage

● Professional software UI with great features for imaging analysis 

● Single or Multi laser Channel, laser power control accuracy up to 0.01%,

● Silicon PMT detector enabling higher photon dynamic range and less noise.

● Support high-speed scanning: 30fps@512x512 Pixels(Resonant scanner)

● Compact Modular design, able to adapt to most microscope system 

● Multiple upgrade options for future capability expansion with low cost 

Product Brochure Link: 



  Confocal Optical Layout

Standard Wavelength:



Optional Wavelength

UV:375 nm





6 Channel Laser module is optional

                Confocal Unit Optical Layout


High Sensitivity Four Channel Laser + Control System

● Equipped with a 4-Channel diode laser and control PCB board to realize the High-speed Low-cost independent adjustment of each laser channel, 

● Laser intensity adjustment accuracy of 0.01%.

● TTL / Analog modulation



Silicon PMT Detector Enabling Higher QE and Less Noise

SIMSCOP CM Series confocal microscope equipment with SiPM Detector 

● Low-voltage operation

● Long operating life,

● Wider dynamic range

● Insensitivity to the magnetic field 

● Suitable for High-speed and High-SNR imaging


Silicon photomultipliers (SiPMs) consist of an array of SPADs fabricated on a shared substrate, with outputs into a shared readout channel (c). Each element acts as an all-or-none photon detector that produces a pulse of stereotypic height with low variability (d). Pulses from all elements sum to form the SiPM output. A large number of elements in the array (>1000) allows many photons to be detected simultaneously without saturation and enable large active areas compatible with large-etendue objectives. 


Product specifications and Brochures

Product Brochure Link: 

SIMSCOP - P Series Laser Scanning Confocal Microscope
Laser Light Source    Standard wavelength:405±5 nm; 488nm±5nm; 561nm±1nm; 640nm±5nm
    Output mode:single-mode polarization-maintaining fiber (TEM00)
    Single wavelength output power: >20mW; Power stability: <1%
    Spectral linewidth: <3nm
    TTL modulation, 1kHz
    Accuracy of laser power adjustment: 0.1%; Multi-wavelength AOTF power   adjustment
    Optional wavelengths include 375nm/ 445nm/473nm/ 515nm/525nm /532nm/633nm              /660nm/ 685nm/785nm/808nm
Detectors    SiPM,Wavelength:250-950nmQE>25%@420nm
    GaAs PMT, 300-740nm45%@520nm
Scan Module    Scanning pixels 128x128 ~ 4096x4096
    Pixel time 0.5 μs -100 μs
    Maximum scanning speed: up to 4fps ( 512 x 512)
XY Resolution    230nm@100x Oil objective
Image Depth    <100um
FOV    5X:1.44mmx1.44mm,          10x:0.72mmx0.72mm ,     20x:0.36mmx0.36mm,   
    40x:0.18mmx0.18mm,          60x:120umx120um,         100x:72umx72um
Filter Unit    DAPI EM 445nm/50nm,     FITC EM   530nm/50nm
    TRITC EM 605nm/60nm,   Cy5 EM   695nm/40nm
Pinhole    16 photoetching pinholes; Pinhole diameter range:Ø25 µm to Ø2 mm
Eyepiece     WF10X/23 wide field eyepiece,; High eye point; Centering telescope
Eyepiece Tube     45°inclined,50‒75mm adjustable interpupillary distance; Adjustable   diopter
Objective Converter     Converter with five-hole internal positioning ; Ball bearing for internal   positioning
Stage    Manual: 240mm x 260mm fixed stage; Range of   movement:135mm x 85mm
    Motorized: Minimum step size:50nm; Repeatability +/- 0.1 μm
    Maximum speed:≥100mm/s;   Stage size:≥270x170mm
    Stroke : X:110mm,Y:75mm; Maximum load capacity >1KG (Horizontal)
Z Driver    Focusing resolution/minimum step size: 0.05μm; Repeatability: +/-0.2μm;  
    Maximum stroke:10mm
Focusing Mechanism    Coaxial coarse/ fine adjustment with limit and locking devices,
     Low level coaxial focusing handwheel   ; Handwheel graduations of fine adjustment:1μm
Transmitted Illumination System    Warm LED light, continuously adjustable brightness
    Brightness adjuster with LED rotation
    Condenser:72mm ultra-long working distance,NA=0.30; Equipped with a three-hole              phase contrast annular plate
Epi-fluorescence Illumination System    Multi-band LED light source MG-100
    6-hole fluorescence module
    UV(U)EX:375/30nm;      DM:415;EM:460/50nm
    Blue(B)EX:475/30nm;    DM:505;EM:530/40nm
    Yellow(Y)EX:540/25nm;   DM:565;EM:605/55nm
    Red(R)EX:620/50nm;    DM:655;EM:692/45nm
Software Feature    Multi-color fluorescence localization processing; Z-stack data   processing; Large image        stitching; Image analysis; Imaging data management;   3D imaging constrution

Professional Software UI Design

SIMSCOP CM Series Confocal Microscope Software Key Features

Laser Control Panel

Microscope Image Acquisition Parameter Settings

Functional GUI Panel
Easy-to-recognize display for setting lasers, detectors, etc.Camera parameter settings
Image processing & deconvolution

Upgrade to Confocal Raman Microscope

● 532,785,1064 Raman

● Upright Microscope setup

● High Resolution with Raman image mapping

Details Click here

Upgrade to Fluorescence lifetime imaging microscopy (FLIM) 

FLIM is a type of microscopy that allows for the visualization and analysis of biological samples based on the fluorescence lifetime of the fluorophore being used. FLIM measures the time between the excitation and emission of photons in a sample, which can provide information about the properties of the fluorophore and the environment in which it is located.

FLIM can be used to study a wide range of biological processes, including protein-protein interactions, enzyme activity, and ion concentration changes. It is often used in combination with other imaging techniques, such as confocal microscopy, to provide more detailed information about the sample.

Upgrade to Single / Two /Multi Photon Microscope

In two-photon microscope, a laser emits light at a specific wavelength that is absorbed by the fluorescent molecules in the sample. When two photons of this light are absorbed simultaneously, they provide enough energy to excite the fluorescent molecule and cause it to emit light at a longer wavelength, which can be detected by the microscope. Because two photons are required to excite the molecule, the probability of fluorescence emission is low and only occurs at the focal point of the microscope, allowing for high-resolution imaging and greater depth than conventional microscopes.

Two-photon microscopy has a number of applications in neuroscience, biology, and biomedical imaging. For example, it has been used to study the activity of individual neurons in the brain, visualize the structure and function of blood vessels, and track the behavior of cells in living tissues.

Upgrade to Confocal Spectral Microscope (Near IR I/II Confocal)

● Upgrade to Confocal Spectral Microscope (NIR I/II confocal)

● Wavelength Range UV to NIR (200nm-2.5nm)

● Spectral resolution up to 0.2nm

● Large NA setup for high-sensitivity application

Details Click here

Upgrade to High Speed Lines Scan Confocal Microscope

● Frame Rate 210fps 

● Resolution: 150 nm over the optical diffraction limit

● Imaging Depth of 500 to 1000 microns 

● Image Contract enhancement 20-30 dB

Click Here for More Info

Upgrade to Terahertz Confocal Microscope System

100GHz, output power: 80mW

● Spatial resolution 150-200um

The terahertz confocal microscope uses a focused beam of terahertz radiation to scan the sample being analyzed. This beam is then reflected back and collected by a detector, which creates an image of the sample based on the intensity of the reflected radiation. By using a confocal design, this microscope can achieve high resolution and can selectively focus on different depths within a sample.

 it can be used to study the microstructure and properties of materials, such as polymers, ceramics, and semiconductors, and to detect defects or anomalies in their structures. In biology and medicine, it can be used to image and study biological tissues, including skin, teeth, and cartilage, which are transparent to terahertz radiation.

Upgrade to Super Resolution Confocal Re-scan Structure illumination Microscope

A "re-scan" confocal microscope is a type of confocal microscope that uses a rapidly moving mirror or scanner to scan the laser beam across the sample multiple times, producing even higher resolution and better contrast images than standard confocal microscopes.

Overall, re-scan confocal microscopes are very powerful tools for studying biological tissues, cells, and other samples, and are widely used in research labs, medical facilities, and other scientific settings

Upgrade to Low Temperature Confocal Microscope

Compatible with SIMTRUM Cryostat to perform Low-temperature Raman measurements -190 to 600 degrees

● 8 probe arm able to upgrade to adjustable probe arm

● Reflection or transmission mode available

Point Scan Confocal Imaging Acquistion Altas

High-definition Visual Assets: Should you require high-definition authentic images and video footage, we invite you to get in touch with us.

Mouse nerve, SIMSCOP Pseries, 20X objective lens

Detector SIPM (Original Image)

Fibrous connective tissue section, SIMSCOP P Series, 10X objective lens_1000x1000, Detector SIPM (Original Image)

Sago palm leaf, SIMSCOP Pseries, 10X objective lens_500x500

Detector SIPM (Original Image)

Sago palm leaf, SIMSCOP Pseries, 10X objective lens_800x800

Detector SIPM (Original Image)



P Series Box


P Series


P Series


L Series


L Series





SIM Basic SpinDisk SIM
Image Frame Rate 4fps@512x512 4fps@512x512 4fps@512x512 10fps@1024x1024 14fps@1024x1024 100fps@2048x2048 100fps@2048x2048 13fps@1024x1024 13fps@1024x1024
Resolution ~230 nm  ~230 nm  ~230 nm  ~230 nm  150-200nm ~230 nm  ~230 nm  ~100 nm  ~100 nm 
Image Depth <100µm <100µm <100µm <100µm <600µm <200µm <200µm <50µm <200µm
No. of Laser  1 1 4 1 4 4 4 4 4
Wavelength Choice 



















Detectors Detector Detector Detector CMOS Camera sCMOS Camera sCMOS Camera Dual sCMOS Camera(Single sCMOS optional) sCMOS Camera Dual sCMOS Camera(Single sCMOS optional)
Microscope  Non Inverted (Upright Customizeable) Inverted (Upright Customizeable) Inverted (Upright Customizeable) Inverted (Upright Customizeable)

Inverted or


Inverted or


Inverted or


Stages Non

Z Motorized

XY Manual

XYZ Motorized  Z Motorized
XY Manual
XYZ Motorized  XYZ Motorized  XYZ Motorized  XYZ Motorized  XYZ Motorized 
Electronics system     Motorized Filter
Motorized Pin hole
  Motorized Filter Motorized Filter Motorized Filter Motorized Filter Motorized Filter
image contrast Medium Medium High Medium High High High High High
Upgrade option Non Non Upgrade to 30fps high Speed  Non Non Non Upgrade to SPIN Disk SIM 100nm resolution Upgrade to SPIN Disk SIM 100nm resolution Non
Customized Option     Yes   Yes Yes Yes    
Applications Biomedicine: monochromatic fluorescence microscopic   observation of cells, 3D scanning; Biomedicine: monochromatic fluorescence microscopic   observation of cells, 3D scanning;
Biomedicine: three-dimensional fluorescence microscopy imaging observation of cells and tissues, multi-channel fluorescence detection
Reflective 3D microscopic imaging, surface shape detection,   rapid analysis and measurement of materials and microelectronic device   surface shape Fast 3D imaging of thick tissue, 3D histopathological image   detection, 3D histomorphological research of small animal tissues and organs   such as brain neurons, liver, kidney, etc. Dynamic fluorescence imaging of living cells/tissues,   microscopic observation of small animals such as zebrafish and nematodes Dynamic fluorescence imaging of living cells/tissues,   microscopic in vivo observation of small animals such as zebrafish and nematodes, and in vivo observation of multi-channel fluorescent organelles. Dynamic fluorescence super-resolution imaging of living cells   can be used for live cell dynamics, allowing tracking of biological changes   at cellular and subcellular levels Dynamic fluorescence super-resolution imaging of living cells,   3D imaging of tissues, organoids, spheroids and small organisms.


Wide Field Raman Microscope Fluorescence / Photoluminescence Microscope Time Correlated Single Photon Counting (TCSPC) For SPAD Testing 


XY Microscope Piezo Stages
Model ST-XY3-11075 ST-XY2-7550
Stroke(mm) 110 X 75 75 X 50
Driver Piezoelectric Motor Piezoelectric Motor
Maximum Load Capacity(KG) 1 1
Maximum Speed(mm/s) 100 100
Minimum Step Size(nm) 20 (50, 100nm for option) 50
Repeatability(nm) +/-200 +/-200
Position Sensor Grating Grating
Material Aluminum Alloy Aluminum Alloy
Weight(KG) 3.3 2.5

We are here for you!

Drop us an email at to get the Best Price today.

Want more technical information? Click Here for the professional Customized System/ Solutions.

Don't have time to search the products one by one? No worries. you can download the full range of SIMTRUM Product Line Cards.

Click it now.

Want to stay closer to the Market Dynamics and Technological 

Developments? Just take 5 seconds to Sign In as a member of 

SIMTRUM, we will bring you the most up-to-date news. 

(Sign in button on the top right of the screen).

Search Reset
Compare Model Drawings & Specs Availability Reference Price
Laser Scanning Confocal Microscope, Standard Wavelength 405/488/561/640nm(638nm), dual-axis XY high-speed optical scanning galvanometer, field of view 15x15mm, scanning pixels 512x512 ~4096x4096, scan speed up to 4fps, stroke: X-110mm, Y-75mm, Z-9mm
In Stock Request for quote

SIMSCOP P Series - Parameter

SIMSCOP P Series - Download


Compare Model Drawings & Specs Availability Reference Price